Optical clearing permits 3-D studies of tissue organization and cellular circuitry at an unprecedented detail following the removal of scatterers and absorbers.
Researchers nowadays face choices among clearing agents that ideally would require investigating the strengths and limitations of different techniques for the very biological question under study.
Also, even the fastest clearing protocols are still prohibitively slow for medical applications.
BRG4 indiscriminately clears soft mammalian tissue, insects, plants, but also hard tissue like bones or teeth.
BRG4 is an ultra-fast universal clearing agent for imaging biological fluorescence in research, biomedical and histological applications.
It is non-toxic, sample volume- and fluorophore preserving.